HERMES is an international collaboration to investigate the genetic basis of heart failure. This unique global effort currently comprises 51 population-based cohorts, case-control studies and randomized clinical trials, including over 65,000 heart failure cases.
We aim to generate insights into the causal pathways leading to heart failure to inform new therapeutic approaches. We combine large-scale genome-wide association analysis with Mendelian randomisation for causal inference and drug target validation.
Our latest GWAS summary statistics is available for download from the Cardiovascular Disease Knowledge Portal
heart failure patient samples
genetic variants analysed
Large-scale meta-analysis of genome-wide association studies of heart failure with 47,309 cases and 930,014 controls of European ancestry